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Research team from LISM unit (Laboratoire d'Ingénierie des Systèmes Macromoléculaires)
Publications
Nguyen VS, Logger L, Spinelli S, Legrand P, Huyen Pham TT, Nhung Trinh TT, Cherrak Y, Zoued A, Desmyter A, Durand E, Roussel A, Kellenberger C, Cascales E, Cambillau C.
Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nature Microbiol. 2017 Jun 26;2:17103. doi: 10.1038/nmicrobiol.2017.103.
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Logger L, Aschtgen MS, Guérin M, Cascales E, Durand E*. (corresponding author*)
Molecular dissection of the interface between the Type VI secretion TssM cytoplasmic domain and the TssG baseplate component.
Journal of Molecular Biology. 2016 Nov 6;428(22):4424-4437.
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Zoued A, Cassaro CJ, Durand E, Douzi B, España AP, Cambillau C, Journet L, Cascales E.
Structure-function analysis of the TssL cytoplasmic domain reveals a new interaction between the Type VI secretion baseplate and membrane complexes.
Journal of Molecular Biology. 2016 Nov 6;428(22):4413-4423.
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Vincent M, Durand E, Cascales E.
The PorX Response Regulator of the Porphyromonas gingivalis PorXY Two-Component System Does Not Directly Regulate the Type IX Secretion Genes but Binds the PorL Subunit. Front Cell Infect Microbiol. 2016 Aug 31;6:96.
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Sana TG, Flaugnatti F, Lugo KA, Lam LH, Jacobson A, Baylot V, Durand E, Journet L, Cascales E, and Monack DM.
Salmonella typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5044-51.
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Zoued A1, Durand E1*, Brunet YR, Spinelli S, Douzi B, Guzzo M, Flaugnatti N, Legrand P, Journet L, Fronzes R, Mignot T, Cambillau C, Cascales E*. (co-first author1 & co-corresponding author*)
Priming and polymerization of a bacterial contractile tail structure.
Nature. 2016 Mar 3;531(7592):59-63.
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Durand E, Nguyen VS, Zoued A, Logger L, Péhau-Arnaudet G, Aschtgen M-S, Spinelli S, Desmyter A Bardiaux B, Dujeancourt A, Roussel A, Cambillau C, Cascales E and Fronzes R.
Biogenesis and structure of a bacterial Type VI secretion membrane core complex. Nature. 2015 Jul 30;523(7562):555-60
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Nguyen VS, Logger L, Spinelli S, Desmyter A, Le TT, Kellenberger C, Douzi B, Durand E, Roussel A, Cascales E, Cambillau C.
Inhibition of type VI secretion by an anti-TssM llama nanobody. PLoS One. 2015 Mar 26;10(3):e0122187
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Durand E, Cambillau C, Cascales E, Journet L.
VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors. Trends Microbiol. 2014 Sep;22(9):498-507.
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Zoued A, Brunet YR, Durand E, Aschtgen MS, Logger L, Douzi B, Journet L, Cambillau C, Cascales E.
Architecture and assembly of the Type VI secretion system. Biochim Biophys Acta. 2014 Aug;1843(8):1664-73.
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Douzi B, Spinelli S, Blangy S, Roussel A, Durand E, Brunet YR, Cascales E, Cambillau C.
Crystal structure and self-interaction of the type VI secretion tail-tube protein from enteroaggregative Escherichia coli. PLoS One. 2014 Feb 14;9(2):e86918
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Blocquel D & Habchi J, Durand E, Sevajol M, Ferron F, Erales J, Papageorgiou N, Longhi S.
Coiled-coil deformations in crystal structures: the measles virus phosphoprotein multimerization domain as an illustrative example. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1589-603.
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