The VN2M team aims to Identify, to Understand, to Block and to Hijack bacterial nanomachines that challenge human health.

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Caine joins VN2M

Caine joins our team for his Master 2 internship.

He will work on T6SS membrane complex with Ona (PhD student).


Our team has been set up in January 2020. The main topic is study the 3D architecture and functioning of bacterial nanomachines which play a role in bacterial virulence during human infection, such as respiratory infection and cancer development. Our team works hands in hands with clinicians to identify many more virulence factors... 

Recent Publications

Cherrak, Y., I. Filella-Merce, V. Schmidt, D. Byrne, V. Sgoluppi, R. Chaiaheloudjou, S. Betzi, et al. « Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex ». mBio 12, no 4 (s. d.): e01348-21.

Crepin A, Kučerová Z, Kosta A, Durand E, Caffarri S. Isolation and characterization of a large Photosystem I-Light Harvesting complex II supercomplex with an additional Lhca1-a4 dimer in Arabidopsis. Plant J. 2019 Dec 6. doi: 10.1111/tpj.14634. PMID: 31811681

Chiara Rapisarda, Yassine Cherrak, Romain Kooger, Victoria Schmidt, Riccardo Pellarin, Laureen Logger, Eric Cascales, Martin Pilhofer, Eric Durand*, Remi Fronzes* (co-corresponding author*). In situ and high-resolution Cryo-EM structure of the Type VI secretion membrane complex. EMBO Journal. 2019 Mar 15. pii: e100886. doi: 10.15252/embj.2018100886.  PMID: 30877094

Cherrak Y, Rapisard C, Pellarin R, Bouvier G, Bardiaux B, Allain F, Malosse C, Rey M, Chamot-Rooke J, Cascales E, Fronzes R and Durand E* (corresponding author*). Biogenesis and structure of a type VI secretion baseplate. Nature Microbiol. 2018 Dec;3(12):1404-1416. doi: 10.1038/s41564-018-0260-1